Euphorbia Herb Fights Candida, Cancer and 5 Other Conditions
Euphorbia hirta and related species of Euphorbia have been used as medicinal medicines around the world for thousands of years. Euphorbia treatments are included in Ayurvedic medicine, Kampo, Malaysian medicine, Polynesian medicines along with Thai, South African and Indonesian medicines.
The plant goes by various names. These include:
- Red spurge
- Pill-bearing spurge
- Mexican Shrubby Spurge
- Caribbean copper plant
- Asthma herb
- Daun biji kacang
Euphorbia is a short skinny tree with red leaves and branches. It is indigenous to many tropical regions, and is cultivated throughout the Southern United States among other regions.
It also grows throughout the world, including in Asia, Pacific Islands, Africa, Central America and South America.
Its beautiful red leaves are hardy in full sun or partial shade. The small branches contain a milky sap. The sap can irritate the eyes and skin for some, so testing is necessary before application.
Nonetheless, the sap, leaves and branches have been used as a remedy for several conditions. Here is a list of these, starting with those that have been confirmed in modern research:
A number of studies have shown that Euphorbia herb contains antifungal properties. 2017 research from France’s University of Lyon studied extracts from Euphorbia and found two that significantly inhibited the growth of anti-drug resistant strains of Candida albicans.
Another 2017 study, this from Portugal’s Research Institute for Medicines, studied Euphorbia extracts. They found that diterpenes from the plant significantly inhibited Candida growth by changing the fungi’s efflux pumps, which they use to become resistant to drugs.
A 1996 laboratory analysis of Malaysian plants found that Euphorbia also inhibited other fungi, including Colletotrichum capsici, Fusarium pallidoroseum, Botryodiplodia theobromae, Phomopsis caricae-papayae, and Aspergillus niger.
Euphorbia has been found to inhibit several cancers.
A 2017 study from Pakistan’s University of Karachi found that Euphorbia herb species inhibited the growth of human lung cancer cells, human breast cancer cells, human prostate cancer cells and human cervical cancer cells.
Research from Africa’s University of the Witwatersrand found that extracts from Euphorbia fight lung cancer cells by inducing cell death. The researchers found cell death rates caused by the extracts were consistent with chemotherapy rates.
Researchers from the College of Pharmacy of Saudi Arabia’s King Saud University performed laboratory analyses on Euphorbia cotinifolia.
The research determined that the plant’s compounds were significant antioxidants. But the most significant finding was that the extracts inhibited the growth of human liver cancer cells – hepatocellular carcinoma cells.
About 2% of all cancers are liver cancer, but liver cancer is severe and not often diagnosed early. Only about a fifth of all liver cancer patients live past one year after diagnosis.
Hepatocellular cancer is the leading type of liver cancer. It often occurs when the liver is damaged from alcohol overuse, hepatitis, the overuse of pharmaceuticals, as well as a number of synthetic compounds such as vinyl chloride, herbicides and others.
A 2006 study showed that the plant medicine also inhibited the growth of skin cancer.
3. Bacterial infections
Other studies have shown that Euphorbia herb inhibits the growth of several types of bacteria. These include E. coli, Bacillus subtili, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumonia.
4. Malaria and other parasites
A 2006 study found that Euphorbia extracts stopped the proliferation of Plasmodium falciparum – the parasite that causes malaria. This was also confirmed in a 1999 study.
A 2000 study from the University of Kinshasa found that Euphorbia hirta also significantly inhibited the growth of Entamoeba histolytica parasites.
Research from France’s University of Metz found in 1991 that Euphorbia herb reduced inflammation and pain.
Another French study found that Euphorbia significantly inhibited several key enzymes. These included enzymes with pro-inflammatory results.
The combination of these effects also support the ability of this powerful herb to reduce pain and inflammation.
Euphorbia contains a powerful flavanoid called quercitrin. This and other compounds give the herb a power antioxidant effect. Antioxidants reduce free radicals – which produce inflammation.
6. Asthma and breathing difficulty
Ayurvedic texts have detailed that Euphorbia significantly relaxes the bronchial airways. This gives it the ability to aid asthma attacks and help curb inflammation in asthma. The effects found in the research above appear to support this use.
A 2016 study from Togo’s University of Lome studied 121 patients with asthma who were treated with Euphorbia along with 6 other herbs. The researchers found the herb to be effective in reducing symptoms.
Traditional medicines have used Euphorbia to help curb diarrhea. Laboratory research has found this effect. This use by traditional medicines is supported by the research showing the herb inhibits bacteria, fungi and parasites. These are often the cause of diarrhea.
Euphorbia contains many constituents, including at least a dozen of macrocyclic diterpenes and 17 different polyphenols.
Specific constituents include quercitrin, kaempferol, amyrin, heptacosane, gallic acid, protocatechuic acid, sitosterol, camphol, nonacosane, choline, quercitol, tinyatoxin, euphorbins (A, B, C, D), jatrophanes, euphopubescenol, methylenecycloartenol, euphomelliferene, myricitrin, afzelin, rutin and two ellagitannins.
This array of constituents – some of which have not been found elsewhere in nature – illustrates the complexity of this plant medicine.
Hopefully researchers will continue to explore this complex medicinal herb. We’ll keep you updated as they do.
Mónico A, Nim S, Duarte N, Rawal MK, Prasad R, Di Pietro A, Ferreira MU. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model. Bioorg Med Chem. 2017 Jul 1;25(13):3278-3284. doi: 10.1016/j.bmc.2017.04.016.
Bano S, Siddiqui BS, Farooq AD, Begum S, Siddiqui F, Kashif M, Azhar M. In vitro growth inhibition and cytotoxicity of Euphorbia caducifolia against four human cancer cell lines and its phytochemical characterisation. Nat Prod Res. 2017 Apr 13:1-5. doi: 10.1080/14786419.2017.1305380.
Nim S, Mónico A, Rawal MK, Duarte N, Prasad R, Di Pietro A, Ferreira MJ. Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps. Planta Med. 2016 Aug;82(13):1180-5. doi: 10.1055/s-0042-106169.
Gbekley HE, Katawa G, Karou SD, Anani S, Tchadjobo T, Ameyapoh Y, Batawila K, Simpore J. ETHNOBOTANICAL STUDY OF PLANTS USED TO TREAT ASTHMA IN THE MARITIME REGION IN TOGO. Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):196-212. doi: 10.21010/ajtcam.v14i1.22.
Marzouk MS, Moharram FA, Gamal-Eldeen A, Damlakhy IM. Spectroscopic identification of new ellagitannins and a trigalloyl-glucosylkaempferol from an extract of Euphorbia cotinifolia L. with antitumour and antioxidant activity. Z Naturforsch C. 2012 Mar-Apr;67(3-4):151-62.
Ogbulie JN, Ogueke CC, Okoli IC, Anyanwu BN. Antibacterial activities and toxicological potentials of crude ethanolic extracts of Euphorbia hirta. Afr J Biotechnol. 2007;6:1544–8.
Suresh K, Deepa P, Harisaranraj R, Vaira Achudhan V. Antimicrobial and phytochemical investigation of the leaves of Carica papaya L., Cynodon dactylon (L.) Pers., Euphorbia hirta L., Melia azedarach L. and Psidium guajava L. Ethnobotanical Leaflets. 2008;12:1184–9.
Liu Y, Murakami N, Ji H, Abreu Pedro, Zhang S. Antimalarial flavonol glycosides from Euphorbia hirta. Pharm Biol. 2007;45:278–81.
Tona L, Ngimbi NP, Tsakala M, Mesia K, Cimanga K, Apers S. Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo. J Ethnopharmacol 1999; 68: 193-198.
Mohamed S, Saka S, EL-Sharkawy SH, Ali AM, Muid S. Antimycotic screening of 58 Malaysian plants against plant pathogens. Pestic Sci. 1996;47:259–64.
Martinez V, Mariano A, Teresa OR, Lazcano ME, Bye R. Anti-inflammatory active compounds from the n-hexane extract of Euphorbia hirta. Rev Soc Quim Méx. 1999;43:103–5.
Tona L, Kambu K, Ngimbi N, Mesia K, Penge O, Lusakibanza M, Cimanga K, De Bruyne T, Apers S, Totte J, Pieters L, Vlietinck AJ. Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo. Phytomedicine. 2000 Mar;7(1):31-8.
Sharma NK, Dey S, Prasad R. In vitro antioxidant potential evaluation of Euphorbia hirta L. Pharmacologyonline. 2007;1:91–8.
Chopra RN, Chopra IC, Handa KL, Kapur LD. Calcutta, India: Academic Publishers; 1994. Indigenous drugs of India