IBS Treated with Fennel Essential Oil and Curcumin
Natural remedies for irritable bowel syndrome (IBS) are relevant because conventional medicine hasn’t figured out how to resolve IBS. There are a number of drugs being prescribed for IBS, such as Lubiprostone (Amitiza) and Alosetron (Lotronex). But these can come with several adverse side effects.
Side effects for these drugs include bloating, nausea, heartburn, headaches, skin rashes and others. Interestingly, some of these side effects replicate some of the very symptoms of IBS. Why? Because pharmaceutical medicine seeks a single-bullet to resolve a set of symptoms.
Nature works differently. It helps resolve the cause of the condition using numerous compounds that synergize to buffer and support each other’s effects.
Fennel oil and curcumin reduce IBS symptoms
In a 2016 study, researchers from the University Medical School in Bari, Italy studied irritable bowel syndrome (IBS) in 121 patients. The patients had been diagnosed with mild to moderate IBS.
The researchers divided the patients into two groups. One group received a placebo. The other group received a blend of curcumin and fennel essential oil. Both groups were treated for one month.
Curcumin is a central active compound of turmeric.
The researchers tested the effectiveness of the treatment using the Irritable Bowel Syndrome Symptom Severity Score (IBS-SSS) and Visual Analogue Scale (VAS) abdominal pain scores. They were also tested for quality of life scores using the IBS-QoL questionnaire.
In the beginning of the treatment, the patients had IBS-SSS scores between 100 and 300. And VAS abdominal pain scores were between 30 and 70 mm (on a 100 mm scale).
After the 30 days of treatment, the researchers found the curcumin and fennel essential oil combination significantly decreased IBS symptom severity scores (IBS-SSS) by an average of 50 points. Remember, their scores ranged from 100 to 300, so this is significant.
The curcumin and fennel essential oil combination also reduced pain scores similarly.
In addition, 26 percent of the patients who took the curcumin and fennel essential oil combination were symptom-free at the end of the 30 days. This compared to less than 7 percent in the placebo group.
This means nearly four times as many patients were symptom-free after taking the herbal combination.
Fennel is antifungal
One of the reasons fennel might be so effective in combination with curcumin relates to its antifungal properties. This is also supported by the fact that many people with IBS have an overgrowth of yeasts.
Yeast species known to over-populate the gut include:
• Candida albicans
• Candida tropicalis
• Candida glabrata
• Candida spp. (other species)
• Aspergillus spp.
• Mucor spp.
• Basidiobolus ranarum
• Cryptococcus neoformans
• Penicillium marneffei – seen in Asian countries
• Histoplasma spp. – seen in Ohio and Mississippi Rivers
Yeasts involved in the vast majority of intestinal infections are Candida species and Aspergillus species.
One of the reasons fennel may be effective in many IBS cases is its antifungal properties. In a 2017 study, scientists from Portugal’s University of Coimbra tested fennel essential oil in the laboratory against several yeasts.
The research found the fennel essential oil was significantly antifungal against Cryptococcus neoformans and Candida albicans. It was also antifungal against dermatophytes and Aspergillus species.
The researchers found the active compounds in fennel oil included:
• Anethole (47%)
• Phellandrene (11%)
• Pinene (10%)
• Fenchone (11%)
Other research has shown that pinene and anethole are significantly antifungal.
The Spanish research also found fennel oil bothers yeast, but not human tissue cells. A 1.25 uL/mL concentration was safe for skin cells (keratinocytes), liver cells (hepatocytes) and connective tissue cells (fibroblasts). This means that fennel kills yeast cells but is safe for human cells. Why? Because nature is smart.
Curcumin is anti-inflammatory and antifungal
Other studies have shown that curcumin is also an antifungal agent. Researchers from Sun Yat-sen University found in a 2016 study that curcumin reduced fungal burden.
Curcumin has also been shown to reduce inflammation. A 2017 study from Zhengzhou University found that curcumin inhibited angiotensin II related inflammation. This relates directly to the type of inflammation that makes IBS painful.
In other words, fennel essential oil and turmeric’s extract, curcumin, does a two-step on IBS. It knocks down fungi and reduces inflammation.
All with no adverse effects. The researchers said the curcumin-fennel treatment was:
“… safe, well-tolerated and induced symptom relief in patients with IBS.”
Portincasa P, Bonfrate L, Scribano ML, Kohn A, Caporaso N, Festi D, Campanale MC, Di Rienzo T, Guarino M, Taddia M, Fogli MV, Grimaldi M, Gasbarrini A. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. J Gastrointestin Liver Dis. 2016 Jun;25(2):151-7. doi: 10.15403/jgld.2014.1121.252.ccm.
Cabral C, Miranda M, Gonçalves MJ, Cavaleiro C, Cruz MT, Salgueiro L. Assessment of safe bioactive doses of Foeniculum vulgare Mill. essential oil from Portugal. Nat Prod Res. 2017 Mar 2:1-6. doi: 10.1080/14786419.2017.1292266.
Lamps LW, Lai KK, Milner DA Jr. Fungal infections of the gastrointestinal tract in the immunocompromised host: an update. Adv Anat Pathol. 2014 Jul;21(4):217-27. doi: 10.1097/PAP.0000000000000016.
Huang L, Zhang J, Song T, Yuan L, Zhou J, Yin H, He T, Gao W, Sun Y, Hu X, Huang H. Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii. Int Immunopharmacol. 2016 May;34:263-70. doi: 10.1016/j.intimp.2016.03.010.
Li HY, Yang M, Li Z, Meng Z. Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress. Int J Mol Med. 2017 Mar 20. doi: 10.3892/ijmm.2017.2924.