Mulberry (Morus alba) leaf and stem come with a long history of success in traditional medicines.
They have been used for a variety of blood and metabolic disorders.
Modern research is now finding that extracts from mulberry leaf and/or stem can seriously help correct conditions related to diabetes, poor cholesterol and weight gain.
Let’s take a quick look at the research proving these out:
In a 2017 study from the UK’s University of Southampton, researchers tested 37 patients with glucose control problems. They tested single doses of mulberry extract together with maltodextrin to test mulberry’s ability to help control blood glucose levels.
On three test periods, the researchers found the mulberry helped control glucose levels by betwen 22 and 24 percent using double doses. The researchers concluded:
“Mulberry leaf extract significantly reduces total blood glucose rise after ingestion of maltodextrin over 120 minutes. The pattern of effect demonstrates a classical dose response curve with significant effects over placebo. Importantly, total insulin rises were also significantly suppressed over the same time-period.”
In a 2016 clinical study, researchers tested 38 type-2 diabetes patients. They split the patients into two groups. For six months, one group was given an extract from mulberry stems. The other group was treated with the diabetes drug acarbose.
Acarbose is a drug that has been shown to reduce and help control blood sugar in diabetes patients. The drug also comes with side effects that can include allergic reactions, swelling of the face, throat or mouth, severe itching, stomach pain, severe constipation or watery, diarrhea stools. The drug can also produce bleeding in other parts of the body.
After the treatment period, the doctors found that glycated hemoglobin (HbA1c) levels improved significantly in both groups. They also found that blood sugar levels one-hour and two-hours after eating were significantly reduced. And fasting blood sugar levels were also improved.
This is called glycemic control – when blood sugar levels don’t spike so much. The blood sugar is in better control.
Yes, the mulberry stem extract significantly improved blood sugar levels, but the acarbose drug had similar effects.
However, the difference is the mulberry group did not have any adverse side effects, while a full third of the acarbose group complained of adverse gastrointestinal effects.
The researchers concluded:
“Compared with acarbose, SZ-A [mulberry stem extract] tablet was effective and safe in glycemic control in patients with type 2 diabetes.”
Research from Italy’s F. De Ritis Institute and the Catholic University of Sacred Heart has determined that a traditional herb used for thousands of years can significantly help stimulate weight loss among obese or overweight people.
The researchers tested 46 overweight people for 90 days. They divided the subjects into two groups. Both groups were given an identical “balanced” diet plan that consisted of 1300 calories per day.
In addition to the diet, one group was given 2.4 grams of white Japanese mulberry extract per day, while the other group was given a placebo. Both groups were followed and tested every 30 days for weight, along with waist and thigh circumference measurements.
The researchers found that the group given the mulberry extract lost an average of nine kilograms (almost 20 pounds) in the three month period. Meanwhile, the placebo group lost about a third of that weight – about 3.2 kilograms – during the period.
The average weight loss among the mulberry group equated to about 10% of their total body weight over the three months.
The researchers also found the mulberry group had significantly reduced waist and thigh circumference among the mulberry group.
The extract was a meristematic extract. This means that the apical meristem was used – which is located in the buds, shoots and young leaves of the plant.
This ability of mulberry to reduce carbohydrate breakdown was determined in a 2011 double-blind placebo-controlled study from Japan’s Nippon Medical School. The researchers tested mulberry leaf extract with 76 pre-diabetes patients with blood sugar control problems.
The researchers tested adult volunteers by giving them either a placebo or mulberry leaf extract for 12 weeks. The research found the mulberry leaf extract significantly improved postprandial (post-meal) glycemic control among the patients.
We also reported other research showing that mulberry leaf reduces triglycerides and inflammation.
Other research has found that mulberry leaf inhibits amylase and alpha-glucosidase enzymes, which break down complex carbohydrates into simple sugars. Thus it basically reduces the assimilation of glucose sugars by preventing the break down of polysaccharides into simple sugars. This, in turn, reduces blood glucose levels.
This effect was confirmed by the researchers, as they found the mulberry group’s blood glucose and insulin consumption curves were significantly lower at the end of the study compared to the beginning of the study. The researchers stated:
“Long‐term ingestion of mulberry leaf extract with enriched DNJ content could result in improved postprandial glycemic control in individuals with impaired glucose metabolism.”
Asian silkworm producers have fed their silkworms with mulberry leaf for thousands of years. But this hasn’t been the only use for the mulberry tree. Traditional Chinese medicine has utilized mulberry leaf to reduce respiratory issues, inflammation, blood sugar issues, and constipation for centuries.
Mulberry leaf extract
Lown M, Fuller R, Lightowler H, Fraser A, Gallagher A, Stuart B, Byrne C, Lewith G. Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study. PLoS One. 2017 Feb 22;12(2):e0172239. doi: 10.1371/journal.pone.0172239.
Mengyi Li, Xuemin Huang, Hui Ye, et al. Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 7121356, 10 pages, 2016. doi:10.1155/2016/7121356
Da Villa G, Ianiro G, Mangiola F, Del Toma E, Vitale A, Gasbarrini A, Gasbarrini G. White mulberry supplementation as adjuvant treatment of obesity. J Biol Regul Homeost Agents. 2014 Jan-Mar;28(1):141-5.
Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta. 2001 Dec;314(1-2):47-53.
Asai A, Nakagawa K, Higuchi O, Kimura T, Kojima Y, Kariya J, Miyazawa T, Oikawa S. Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. J Diabetes Investig. 2011 Aug 2;2(4):318-23. doi: 10.1111/j.2040-1124.2011.00101.x.
Aramwit P, Supasyndh O, Siritienthong T, Bang N. Mulberry leaf reduces oxidation and C-reactive protein level in patients with mild dyslipidemia. Biomed Res Int. 2013;2013:787981. doi: 10.1155/2013/787981.
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