Nuts and Probiotics Yield Heart Benefits
New research is finding that when we eat whole natural nuts such as walnuts, hazelnuts and almonds, intestinal probiotics will consume a healthy element from the nuts called ellagitannin.
When our probiotics eat ellagitannins they produce a group of compounds called urolithins. As it turns out, these urolithins prevent artery damage and the resulting inflammation that leads to atherosclerosis – the hardening of the arteries.
In a study from Spain’s Rovira i Virgili University, when patients with metabolic syndrome consumed a moderate amount of nuts daily for twelve weeks, their intestinal bacteria produced higher quantities of these heart-healthy urolithin metabolites. These were found circulating within their bloodstream, while the group that did not eat the nuts did not have these metabolite levels.
Other research confirms findings
In a follow-up study published in May, researchers from Spain’s Research Group on Quality, Safety and Bioactivity of Plant Foods from the government’s Department of Food Science and Technology (CEBAS-CSIC) conducted laboratory studies that confirmed the mechanisms of the urolithin metabolites produced when probiotics consumed nuts. The researchers utilized human cells from the walls of the aortic artery and duplicated inflammation associated with the buildup of artery plaque.
They introduced urolithin A and urolithin B produced from probiotic colonies fed with ellagitannins – which are abundant in nuts and some other plant-based foods.
The researchers found that the urolithins blocked the process of inflammation among the artery cells. This, they discovered, was produced by the urolithins blocking the process of adhesion by pro-inflammatory monocytes.
The researchers concluded that, “our results suggest that these metabolites might be involved, at least in part, in the beneficial effects against cardiovascular diseases attributed to the consumption of ellagitannin-containing foods.”
In April, the Spanish researchers published another study that showed how urolithins produced by probiotic bacteria consumption of pomegranate ellagitannins (as pomegranates, like nuts, have significant quantities of ellagic acid) significantly reduced inflammatory factors within the colon. The study was published in the Journal of Agricultural Food Chemistry.
What all this means is that when we feed our (healthy) intestinal probiotic colonies ellagitannin-containing foods such as nuts and pomegranates, they produce compounds that keep our arteries healthy, keep our colon healthy, and likely reduce inflammation throughout the body.
Giménez-Bastida JA, González-Sarrías A, Larrosa M, Tomás-Barberán F, Espín JC, García-Conesa MT. Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells. Mol Nutr Food Res. 2012 May;56(5):784-96.
Tulipani S, Urpi-Sarda M, García-Villalba R, Rabassa M, López-Uriarte P, Bullo M, Jáuregui O, Tomás-Barberán F, Salas-Salvadó J, Espín JC, Andrés-Lacueva C. Urolithins are the Main Urinary Microbial-Derived Phenolic Metabolites Discriminating a Moderate Consumption of Nuts in Free-living Subjects with Diagnosed Metabolic Syndrome. J Agric Food Chem. 2012 May 27.
Heber D. Pomegranate Ellagitannins. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press; 2011. Chapter 10.
Giménez-Bastida JA, Larrosa M, González-Sarrías A, Tomás-Barberán F, Espín JC, García-Conesa MT. Intestinal Ellagitannin Metabolites Ameliorate Cytokine-Induced Inflammation and Associated Molecular Markers in Human Colon Fibroblasts. J Agric Food Chem. 2012 Apr 16.
Case Adams is a California Naturopath with a PhD in Natural Health Sciences, and Board Certified Alternative Medicine Practitioner. He has authored 26 books on natural healing strategies. “My journey into writing about alternative medicine began about 9:30 one evening after I finished with a patient at the clinic I practiced at over a decade ago. I had just spent the last two hours explaining how diet, sleep and other lifestyle choices create health problems and how changes in these, along with certain herbal medicines and other natural strategies can radically yet safely turn our health around. As I drove home that night, I realized this knowledge should be available to more people. So I began writing about health with a mission to reach those who desperately need this information. The strategies in my books and articles are backed by scientific evidence along with wisdom handed down through traditional medicines for thousands of years.” Case connects with nature by surfing, hiking, running, biking and according to Dad, being a total beach bum.