Herbs and Nutrients that Resist Heat Shock Proteins
Heat shock proteins have been linked with the heating up of cells – but certain heat shock proteins are known to accompany periods of stress, inflammation and toxicity according to the research.
Unhealthy heat shock proteins
Certain heat shock proteins, namely HSP27, HSP65 and HSP70 have been linked specifically to atherosclerosis and metabolic syndrome.
For example, a study of 237 high-cholesterol (hyperlipidemia) patients and 135 healthy volunteers found that the hyperlipidemia patients had higher levels of antibodies to HSP60, HSP65 and HSP70.
Now research is finding that heat shock proteins are reduced by certain traditional herbs and antioxidants.
Saffron decreases heat shock proteins
Research from the Middle East has found that saffron – a traditional herb harvested from the flower of Crocus sativus – has been found to significantly reduce certain heat shock proteins after three months of supplementation.
The researchers measured the antibodies to heat shock proteins 27, HSP60, HSP65 and HSP70 during the treatment of 105 patients with metabolic syndrome. Levels were determined by measuring the antibodies to each type of heat shock protein as higher levels of these HSPs have been linked with greater inflammation and higher risk of metabolic disease. Metabolic syndrome includes higher risks of diabetes, obesity and heart disease.
The researchers randomly divided them into two groups and gave the patients either 100 milligrams per day of saffron or a placebo.
After the three months treatment, the researchers found that antibodies to heat shock proteins 27 and HSP70 were significantly reduced by saffron.
Barberry herb reduces heat shock proteins
In another study, researchers found that the Barberry herb also reduces levels of antibodies to these heat shock proteins. This study tested 106 people with metabolic syndrome. They were given either a placebo or capsules of Barberry herb.
As in the saffron study, the researchers found that antibodies to the heat shock protein 27 was significantly lower among those who took the Barberry herb.
Those who too Barberry also had significant improvements in their C-reactive protein levels and lower LDL-cholesterol levels.
Antioxidants reduce heat shock proteins
The idea that heat shock proteins are reduced by natural strategies was confirmed by a study from the UK’s University of Surrey, which found that diets with greater levels of certain antioxidant nutrients are linked with reduced heat shock proteins.
The researchers tested 238 patients plus 188 control volunteers. They were tested for heat shock proteins and blood levels of antioxidants. The researchers found that antibodies to heat shock proteins 60, 65 and 70 were higher among those with cholesterol issues and heart disease. They also found that those with higher levels of vitamin E and vitamin C had reduced levels of these heat shock protein antibodies.
The bottom line is that there is more to nutrition and herbalism than simple biochemistry. Herbs and antioxidants modulate protein production at the genetic level. The body utilizes antioxidants and herb constituents to improve its management of metabolism from the intelligent aspects of our physiology.
Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Ghayour-Mobarhan M, Ferns GA. Saffron in metabolic syndrome: its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70. J Complement Integr Med. 2014 Feb 6. pii: /j/jcim.ahead-of-print/jcim-2013-0047/jcim-2013-0047.xml. doi: 10.1515/jcim-2013-0047.
Ghayour-Mobarhan M, Rahsepar AA, Tavallaie S, Rahsepar S, Ferns GA. The potential role of heat shock proteins in cardiovascular disease: evidence from in vitro and in vivo studies. Adv Clin Chem. 2009;48:27-72.
Zilaee M, Kermany T, Tavalaee S, Salehi M, Ghayour-Mobarhan M, Ferns GA. Barberry Treatment Reduces Serum Anti-Heat Shock Protein 27 and 60 Antibody Titres and High-sensitivity C-reactive Protein in Patients with Metabolic Syndrome: A Double-blind, Randomized Placebo-controlled Trial. Phytother Res. 2014 Feb 17. doi: 10.1002/ptr.5117.
Ghayour-Mobarhan M, New SA, Lamb DJ, Starkey BJ, Livingstone C, Wang T, Vaidya N, Ferns GA. Dietary antioxidants and fat are associated with plasma antibody titers to heat shock proteins 60, 65, and 70 in subjects with dyslipidemia. Am J Clin Nutr. 2005 May;81(5):998-1004.
Ghayour-Mobarhan M, Lamb DJ, Lovell DP, Livingstone C, Wang T, Ferns GA. Plasma antibody titres to heat shock proteins-60, -65 and-70: their relationship to coronary risk factors in dyslipidaemic patients and healthy individuals. Scand J Clin Lab Invest. 2005;65(7):601-14.
Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial. J Clin Pharm Ther. 2010 Oct;35(5):581-8. doi: 10.1111/j.1365-2710.2009.01133.x.
Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. doi: 10.1002/ptr.3484.
Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SS, Yousefi MH, Alimardani R, Jamshidi A, Rezazadeh SA, Yousefi A, Zare F, Moradi A, Vossoughi A. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology (Berl). 2010 Jan;207(4):637-43. doi: 10.1007/s00213-009-1706-1.
Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009 Aug;16(8):690-3. doi: 10.1016/j.phymed.2009.03.008.